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Writing in Proceedings of the National Academy of Sciences, researchers describe how neurons store their very own glycogen, a form of sugar that helps neurons stay resilient when their primary power sources falter. The findings illustrate how neuron cells can adapt their metabolism, researchers say, and could form new treatments for neurological circumstances like stroke, neurodegeneration, and epilepsy, all disorders by which power failure plays a role. "Traditionally, it was believed that glial cells served as ‘energy warehouses,’ storing glycogen and supplying neurons with gas as wanted," said co-lead creator Milind Singh, a doctoral student in cell biology at the Yale School of Medicine (YSM). "But we now know that neurons themselves store glycogen and may break it down when the stress is on. For the study, the analysis crew used a microscopic roundworm called Caenorhabditis elegans(C. With customized-built devices, researchers precisely managed the level of oxygen the dwelling worms experienced and monitored how neurons responded to power stress in real time.
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